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Skincare for Hyperpigmentation & Dark Spots
With the right skincare routine and scientifically backed products, you can reduce dark spots, prevent new discoloration, and achieve a brighter, more even complexion. See our most effective Skincare products of SkinClinic and iS Clinical.
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Key Factors That Contribute Hyperpigmentation
Hyperpigmentation is the darkening of the skin due to an excess of melanin. It appears as sunspots, melasma, post-inflammatory marks, or uneven tone. Common causes include:
Sun exposure
Exposure to the sun triggers melanin production
Hormonal Changes
During pregnancy or due to use of contraceptives
Post-inflammatory response
Responses of the skin from Acne, eczema or injuries
Genetics & skin type
Some skin is more prone to pigmentation then others
Improper skincare
Harsh peels, picking or no SPF can contribute to Hyperpigmentation
How to Treat Hyperpigmentation
To fade existing discoloration and prevent new spots:
- Target melanin production with brightening serums
- Exfoliate gently to promote healthy skin turnover
- Use SPF daily to prevent darkening
- Moisturize and support skin barrier to reduce inflammation
Be consistent – pigmentation takes time to fade.
We advice a skincare routine based on Cleansing, Treating (serums), Hydrating (Moisteriser) and Protecting (sunscreen) the skin.
You can come by Gustil Aesthetics in Amsterdam for a personalized and FREE consult.
Hyperpigmentation Skincare Products
Recommended Skin Products for Hyperpigmentation and Dark Spots
iS Clinical Pro-Heal Serum Advance+
Why include Pro-Heal Serum Advance+?
Especially effective for post-inflammatory hyperpigmentation (PIH) from acne or irritation. Combines antioxidants with reparative vitamins to brighten and calm the skin.
Key Ingredients
- L-Ascorbic Acid (Vitamin C) – Provides antioxidant protection and reduces the appearance of scars.
- Vitamin E – Enhances skin healing and adds additional antioxidant properties.
- Vitamin A – Reduces fine lines, and helps treat acne-related inflammation.
- Olive Leaf Extract – Offers anti-inflammatory and antimicrobial benefits.
- Zinc Sulfate – Supports skin healing and helps control oil production.
How to use
Apply a few drops to clean skin, focusing on acne-prone areas. It can be used in both the morning and evening for enhanced results.
iS Clinical Active Serum
Why include Active Serum?
This multi-tasking cult favorite is a powerful botanical serum designed to target hyperpigmentation, fine lines, acne, and uneven texture. It works fast to improve brightness and clarity while giving the skin a cool, tingling sensation upon application. Suitable for oily, combination, and blemish-prone skin.
Key Ingredients
- Arbutin & Mushroom Extract – lighten hyperpigmentation and inhibit melanin
- Willow Bark Extract (Salicylic Acid) – exfoliates pores and refines texture
- Sugar Cane Extract (Glycolic Acid) – smooths and boosts cell turnover
- Bilberry Extract (Lactic Acid) – hydrates while exfoliating
- Menthol – provides an instant cooling effect
How to use
Apply 3–5 drops to clean, dry skin in the evening. Gently smooth over the face and neck, avoiding the eye area. Follow with moisturizer if needed. Always apply sunscreen the next morning.
SkinClinic M Cream
Why include SkinClinic M Cream?
A deeply nourishing and regenerating cream that complements Melanyc Serum. It boosts cell turnover, repairs the skin barrier, and enhances the overall brightening effect.
Key Ingredients
- Retinol (Encapsulated) – promotes cell renewal and pigment fade
- Vitamin C – antioxidant and brightening agent
- Glycolic Acid – gentle exfoliation for smoother, clearer skin
- Urea – hydrates and softens texture
- Licorice Extract
- – soothes and naturally lightens pigmentation
How to use
Apply at night after your serum. Introduce gradually (2–3x per week), especially for sensitive skin. Always use sunscreen during the day.
SkinClinic Melanyc Serum
Why include SkinClinic Melanyc Serum?
A professional-grade depigmenting serum designed to reduce all types of hyperpigmentation—from sun damage to melasma—by inhibiting melanin synthesis and evening out skin tone.
Key Ingredients
- Tranexamic Acid – powerful pigment-blocking active
- Niacinamide – reduces inflammation and regulates pigment
- Azelaic Acid – clears blemishes and fades post-acne marks
- Phytic Acid – gently exfoliates and enhances penetration
- Lactic Acid – hydrates while refining texture
How to use
Apply to clean skin in the evening, focusing on pigmented areas. Use SPF the following morning. Can be layered with other SkinClinic or iS Clinical treatments.
Advised Skincare Routine
Morning Routine
- Cleansing Complex from iS Clinical or Foam Cleanser from Skin Clinic or Cleansing Milk from Skin Clinic
- Melanyc Eyes from Skin Clinic (only if you have dark circles
- M Cream from Skin Clinic
- Extreme Protect SPF 40 from iS Clinical or Syl 100 SPF 50 from Skin Clinic
Evening Routine
- Cleansing Complex from iS Clinical or Foam Cleanser from Skin Clinic or Cleansing Milk from Skin Clinic
- Melanyc Eyes from Skin Clinic (only if you have dark circles
- Melanyc Serum from Skin Clinic / morning and/or Melanyc intensive
Every 3 Days
Retinol + Emulsion 0.3 from iS Clinical or Retinol One Million from Skin Clinic/ evening
Additionally:
- Active Peel System from iS Clinical
Why Choose iS Clinical and SkinClinic for Hyperpigmentation Treatment?
- iS Clinical offers science-driven, dermatologist-loved solutions that combine botanical ingredients with clinical results. Their serums are ideal for sensitive skin or inflammation-prone pigmentation.
- SkinClinic brings medical-grade formulations that directly target melanin synthesis and pigment pathways, ideal for stubborn or hormonally driven pigmentation like melasma.
Together, they create a potent, safe, and customizable routine to visibly brighten skin, fade spots, and prevent new pigmentation from forming.
FAQ – Hyperpigmentation Skincare
1. What is the best skincare routine for hyperpigmentation?
A targeted routine includes a brightening serum, exfoliating or retinoid-based cream, daily SPF, and supportive hydration. Use active ingredients like vitamin C, niacinamide, tranexamic acid, and retinol to fade dark spots and improve skin tone.
2. How long does it take to see results from pigmentation treatments?
Most users notice visible improvement in 4–8 weeks, with optimal results after consistent use for 3 months or longer. Melasma or deeper pigmentation may take more time. Patience and daily SPF are key.
3. Can I use SkinClinic Melanyc Serum and M Cream together?
Yes! Melanyc Serum targets pigment production, while M Cream enhances renewal and helps fade discoloration. Use the serum first, followed by M Cream in the evening. Start gradually if you have sensitive skin.
4. Are iS Clinical products safe for sensitive skin?
Yes. iS Clinical serums like Pro-Heal Serum Advance+ are formulated for sensitive or reactive skin, making them ideal for post-acne marks or redness-prone pigmentation.
5. Do I really need sunscreen if I’m treating pigmentation?
Absolutely. Without SPF, pigmentation will return or worsen. Use a broad-spectrum sunscreen with at least SPF 50 every single day, even indoors or in cloudy weather.
6. Can I combine SkinClinic and iS Clinical products?
Yes, they complement each other well. For example, use iS Clinical Pro-Heal in the morning and Melanyc + M Cream at night. Always patch test new combinations if you have reactive skin.
